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Whilst the risk of cardiac death was reduced with epa plus dha but not epa alone, the risk of mi and major vascular events was reduced only with epa alone and not with the combination. The objective was to evaluate the effect of docosahexaenoic acid (dha) and eicosapentaenoic acid (epa) on sperm parameters including total sperm concentration, sperm motility, sperm dha, and seminal plasma dha concentration in infertile men. This commentary summarizes their pharmacology, efficacy, and safety